In lieu of an abstract, here is a brief excerpt of the content:Closing the Gaps in Pediatric HIV/AIDS Care, One Step at a TimeLisa V. Adams, Helga Naburi, Goodluck Lyatuu, Paul Palumbo, and C. Fordham von ReynFatuma's* doctors were completely perplexed. It was 2003 and she had returned to the DARDAR clinic in her hometown of Dar es Salaam, Tanzania three times that week with vague complaints of various pains and aches. Her doctors were considering whether these symptoms were due (...) to the initiation of her recent treatment with antiretroviral medications for her HIV infection or related to the last administration of the investigational tuberculosis (TB) vaccine that the DARDAR Health Study was evaluating. Fatuma's doctor, Dr. Lillian Mtei, consulted with Dartmouth's chief of Infectious Disease, Dr. Ford von Reyn, who happened to be in Dar that week on a site visit. Neither physician could determine the basis for her symptoms. Dr. Mtei returned to the exam room once more and this time emerged with the answer: Fatuma had just learned that her three year old daughter was HIV-infected, likely contracted from Fatuma during or shortly after she gave birth to her daughter. Fatuma believed that her HIV diagnosis was a death sentence for her daughter since antiretroviral therapy was not widely available for children.Dr. von Reyn, Dartmouth's lead clinical researcher in Africa and a father, knew too well the harsh reality of inequities in a resource-limited country. He turned to Dr. Mtei and said decidedly, "we need to do something about this."Thus the DARDAR Pediatric Program was born.Pediatric HIV: A Neglected DiseaseThe need for HIV treatment among children in Tanzania, as in most of sub-Saharan Africa, is compelling. At the end of 2009, approximately 160,000 children aged zero to fourteen in Tanzania were living with HIV (Joint United Nations Programme on HIV/AIDS [UNAIDS], 2011). Even with successful roll out of prevention of mother to child transmission programs in Tanzania, there were nearly 29,000 perinatal infections in 2009. As of December 2010, only 18% of these were enrolled in HIV treatment programs (UNAIDS, 2011; World Health Organization [WHO], 2011). Without antiretroviral therapy (ART), one-half of HIV-infected children will die before their second birthday. Since clinical research to determine efficacy and safety of new medical treatments is conducted almost exclusively in adults, provision of new medical treatments to [End Page 75] children always lags behind advances for adults. Furthermore, children are often underrepresented in programs for antiretroviral drugs for the following reasons: 1) they are not prioritized for care; 2) facilities lack infant diagnostic capabilities; 3) there is limited pediatric HIV training and consequently, a shortage of pediatric providers; and 4) pediatric antiretroviral formulations are frequently unavailable. The unacceptable delays in pediatric HIV drug development and treatment access led the international organization Drugs for Neglected Diseases initiative to publish an editorial in which they referred to pediatric HIV as a "neglected disease" (Lallemant, Chang, Cohen, & Pecoul, 2011).The Tip of the Iceberg: More than Just MedicinesWith a grant from the New York-based Foundation for the Treatment of Children with AIDS, the DARDAR Pediatric Program, a joint collaboration between Geisel School of Medicine at Dartmouth and Muhimbili University of Health and Allied Sciences, began seeing patients in May 2006. It was the first dedicated pediatric HIV Care and Treatment Center in Tanzania and operates in accordance with Tanzania's National AIDS Control Programme's guidance. Testing for both children and infants (the latter of which requires a more sophisticated assay) is available.The day the clinic opened we celebrated this collaborative effort that would provide HIV-infected children in Dar es Salaam access to antiretroviral treatment. One of our first patients was a six-year-old boy whose mother, like Fatuma, was a participant in our TB vaccine trial. She had been advised to bring her son to us for HIV screening. Her son looked healthy so she was surprised and understandably distraught when his test results indicated that not only was he HIV-infected, but his CD4 percentage was very low. His mother was reluctant to have him started on antiretrovirals given his general appearance and young age—and that he was... (shrink)

The spatial dynamics of the optical emission from an array of 50 times 50 individual microcavity plasma devices is investigated. The array is operated in argon and argon-neon mixtures close to atmospheric pressure with an ac voltage. The optical emission is analysed with phase and space resolution. It has been found that the emission is not continuous over the entire ac period, but occurs once per half period. Each of the observed emission phases shows a self-pulsing of the discharge, with (...) several bursts of emission of fixed width and repetition rate. The number of emission bursts depends on applied voltage and frequency. Spatially resolved measurements prove that the emission bursts are formed by overlapping emission pulses from single discharge cavities. Intensity differences between positive and negative half-wave can be interpreted through spatially resolved measurements of single discharge cavities. (shrink)

Mit Descartes' 'Meditationen' setzt eine neue Epoche der Philosophie ein: ohne sie keine 'Kritik der reinen Vernunft', keine 'Wissenschaftslehre' und keine 'Phänomenologie des Geistes'. F.-W. v. Herrmann liest die 'Meditationen' mit phänomenologischem Blick und unter Beachtung der ihnen eigentümlichen Grundhaltung der 'Cartesianischen Epoché': als Grundlegung einer Metaphysik des Selbstbewusstseins aus dem Selbstbewusstsein. Er stellt die Lektüre der sechs Meditationen unter den Leitgedanken der Endlichkeit des Selbstbewusstseins und des Problems der Transzendenz. Denn das endliche Selbstbewusstsein vollzieht sich in einem Gefüge dreifachen (...) Transzendierens. Durch diese Metaphysik des Selbstbewusstseins wird Descartes zum entscheidenden Wegeröffner der großen Metaphysiken der Neuzeit von Spinoza über Leibniz, Kant, Fichte, Schelling bis zu Hegel - und darüber hinaus im 20. Jahrhundert zum Wegbereiter der Transzendentalen Phänomenologie Edmund Husserls. (shrink)

Quantum cognition in decision making is a recent and rapidly growing field. In this paper, we develop an expected utility theory in a context of non-classical uncertainty. We replace the classical state space with a Hilbert space which allows introducing the concept of quantum lottery. Within that framework, we formulate axioms on preferences over quantum lotteries to establish a representation theorem. We show that demanding the consistency of choice behavior conditional on new information is equivalent to the von Neumann–Lüders postulate (...) applied to beliefs. A dynamically consistent quantum-like agent may violate dynamic recursive consistency, however. This feature suggests interesting applications in behavioral economics as we illustrate in an example of persuasion. (shrink)

Context: The paper utilizes a conceptual analysis to examine the development of abstract conceptual structures in mathematical problem solving. In so doing, we address two questions: 1. How have the ideas of RC influenced our own educational theory? and 2. How has our application of the ideas of RC helped to improve our understanding of the connection between teaching practice and students’ learning processes? Problem: The paper documents how Ernst von Glasersfeld’s view of mental representation can be illustrated in the (...) context of mathematical problem solving and used to explain the development of conceptual structure in mathematical problem solving. We focus on how acts of mental re‑presentation play a vital role in the gradual internalization and interiorization of solution activity. Method: A conceptual analysis of the actions of a college student solving a set of algebra problems was conducted. We focus on the student’s problem solving actions, particularly her emerging and developing reflections about her solution activity. The interview was videotaped and written transcripts of the solver’s verbal responses were prepared. Results: The analysis of the solver’s solution activity focused on identifying and describing her cognitive actions in resolving genuinely problematic situations that she faced while solving the tasks. The results of the analysis included a description of the increasingly abstract levels of conceptual knowledge demonstrated by the solver. Implications: The results suggest a framework for an explanation of problem solving that is activity-based, and consistent with von Glasersfeld’s radical constructivist view of knowledge. The impact of von Glasersfeld’s ideas in mathematics education is discussed. (shrink)

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Purpose: Ernst von Glasersfeld has dedicated a lot of effort to trying to define just where his views and those of his friend Humberto Maturana part company, epistemologically speaking (Glasersfeld 1991, 2001). As a contribution to unravelling this puzzle I propose in this article to delineate just where they seem to differ most and why these differences arise. Approach: Part of my contribution is to propose drawing a distinction between von Glasersfeld's Radical Constructivism as the last viable outpost of constructivism (...) before entering into the domain of solipsism, in contrast to Maturana's position which is saved from being located within the solipsistic domain by virtue of his ideas on "structure determined systems" and his theory of how language arises in human experience. Findings: Von Glasersfeld's puzzle arises due to what Kant called "transcendental illusion," that is, the error of trying to encompass two mutually untranslatable phenomenal domains within the same language framework. Conclusion: After an examination of some of the crucial differences between von Glasersfeld and Maturana I typify Maturana's positioning as that of "radical realism" in contrast to von Glasersfeld's "radical constructivism.". (shrink)

Context: The recent death of Ernst von Glasersfeld opens a space in which there is an important opportunity to re-present and highlight key aspects of his life’s work constructing his model of radical constructivism. Purpose: To make available in a synthetic form one of his particular efforts to elaborate RC in a project that lasted 13 years. This particular project was conducted on the Oikos web site under the title of “Ask von Glasersfeld” and consisted of an opportunity for questioners (...) to pose any type of query directly to von Glasersfeld and normally expect a rapid reply. He was busy composing considered answers right up to his death in November 2010. Method: My intention is to re-present the liveliness of his explicatory interactions with all types of questioners by selecting eight categories of “Questions & Answers” from the web site. Because the selected contents are so extensive these eight categories will be presented in a series of four articles of which this is the first. Implications: This re-presentation of von Glasersfeld’s ideas offers an easily accessible resource for people of all levels of understanding who are seeking to deepen their appreciation of his work. One can come to appreciate not only the lucidity of his writings but also glean “insights” into the person himself, who can be glimpsed between the lines of these various interactions. (shrink)

Context: Under the title “Ask von Glasersfeld,” for 13 years the Oikos web site offered the opportunity to questioners to pose any type of query directly to Ernst von Glasersfeld. Purpose: Based on the collected questions and answers gathered on the web site, this series of four articles re-presents and highlights key aspects of von Glasersfeld’s life’s work constructing his model of radical constructivism. Method: The question-answer pairs are grouped into eight categories. Because the selected contents are so extensive, these (...) eight categories are presented in a series of four articles, of which this is the second and which deals with with von Glasersfeld’s views on human experience. The material is divided into two main themes: the first deals with his views on “experiential reality” and the second deals with the issue of “learning.” Results: One of von Glasersfeld’s main objectives was to define clearly that which we can rationally claim to know. As part of this task, in the first section of this article he deals with the question of how we go about constructing our personal experiential reality. The second part deals with his views on how to apply practically the tenets of radical constructivism in a variety of fields. He is especially interested in redefining what “learning” means and in creating novel approaches to teaching and training students. Implications: This re-presentation of von Glasersfeld’s ideas offers an easily accessible resource for people of all levels of understanding who are seeking to deepen their appreciation of his work. One can come to appreciate not only the lucidity of his writings but also glean “insights” into the person himself, who can be glimpsed between the lines of these various interactions. (shrink)

Context: Over a thirteen-year period Ernst von Glasersfeld directly answered a wide diversity of questions posed to him on the Oikos web site. Purpose: This is the fourth and final article in a series that is based on a selection from all of the questions posed in the thirteen-year period and is aimed at giving prominence to key aspects of his radical constructivist approach. Method: This article deals with the issue of “change,” divided into the two main themes of (i) (...) viability as defined by von Glasersfeld and (ii. the processes of personal learning and change. Implications: This ultimate article of this series offers an important source of original material for those readers who are seeking to elaborate their understanding of radical constructivism. (shrink)